** Individual clinical studies may use a specific sub-strain of a Probiotic that shares the same genus and species strain with probiotics included in this formulation. Specific sub-strains in these formulations may not exactly match the sub-strain in the studies included here and may interact differently with each individual’s microbiome. We have gathered the research cited here as examples of some of the outcomes and studies that show particular impacts of strains and sub-strains on study participants within the controls and design of those studies. Each person’s microbiome and results will vary based on environmental and health factors.