Lactobacillus paracasei LPC-37® - Lactobacillus paracasei has been studied for its impact on skin health repeatedly. Studies have shown that some substrains (specifically NCC 2461) have an effect in reducing skin sensitivity, and further studies are underway to explore how that gut-skin-immune connection may impact atopic dermatitis and dandruff as well.
“Several strains of Lactobacillus also demonstrate anti-inflammatory properties. The addition of Lactobacillus paracasei NCC2461 has been shown to inhibit neurogenic inflammation in a skin model. And the addition of L. paracasei NCC2461 to lymphocyte culture has also been shown to strongly inhibit the proliferative activity of CD-4 + T-cells in a dose-dependent manner and to induce the anti-inflammatory cytokines IL-10 and TGF-beta (7). Mice who consumed the probiotic for seven days demonstrated a significantly higher antibody response and in vivo T-cell-mediated immune response, indicating L. paracasei affects both B-and T-cell function (Benyacoub et al., 2014). Similarly, mice treated with Lactobacillus casei had an increased ability to produce IL-10 and promote T-regulatory cell function (Hacini-Rachinel et al., 2009). An increase in T-regulatory cells suggests that this probiotic may help to balance the immune system’s response to stimuli (Hacini-Rachinel et al., 2009, Pellaton et al., 2012). Consequently, certain probiotic strains may potentially boost appropriate immune responses, for example, to a harmful pathogenic threat, while dampening the unnecessary immune responses seen in chronic inflammatory states.” **